After binding to the receptor, IL-17 activates several signalling cascades that, in turn, lead to the induction of chemokines.
In turn, there are at least three variants of IL-17R referred to as IL17RA, IL17RB, and IL17RC. The biologically active IL-17 interacts with type I cell surface receptor IL-17R. In rodents, IL-17A is often referred to as CTLA8. IL17A protein exhibits a high homology with a viral IL-17-like protein ( O40633) encoded in the genome of T-lymphotropic rhadinovirus Herpesvirus saimiri. The protein encoded by IL17A is a founding member of IL-17 family (see below). who isolated IL17A transcript from a rodent T-cell hybridoma. Originally, Th17 was identified in 1993 by Rouvier et al. They are produced by a group of T helper cell known as T helper 17 cell in response to their stimulation with IL-23. Interleukin 17 family ( IL17 family) is a family of pro-inflammatory cystine knot cytokines. Interleukin 17 familyĬrystallographic structure of dimeric human IL-17f.
This article is about the protein family.
